Brefeldin

CAS Number 20350-15-6

γ,4-Dihydroxy-2-[6-hydroxy-1-heptenyl]-4-cyclopentanecrotonic acid λ-lactone; BFA) Purity: 98% Blocks binding of the cytosolic coat protein β-COP and ARF to Golgi membranes mediated by protein G. Also blocks protein transportation into post-Golgi compartments. Ref.: 1. Donaldson, J.G., et al., Science, 254: 1197 (1991). 2. Donaldson, J.G., et al., J. Cell. Biol., 112: 579 (1991). 3. Orci, L., et al. Cell, 64: 1183 (1991). 4. Lippincott-Schwartz, J., et al., ibid., 60: 821 (1990).