Promega

CLK1 Kinase Enzyme System

Recombinant human CLK1 (129-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. CLK1, also known as STY, is a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases.

Recombinant human CLK1 (129-end) was expressed by baculovirus in Sf9 insect cells using an N-terminal GST tag. CLK1, also known as STY, is a member of the CDC2-like (or LAMMER) family of dual specificity protein kinases. The phosphorylated serine/arginine-rich (SR) proteins are involved in the pre-mRNA processing and releasing through nucleus into nucleoplasm. CLK1, which could phosphorylate the specific SR proteins (1) such as ASF/SF2, may directly regulate the activity and compartmentalization of SR splicing factors (2). Kinase Enzyme System contains: Kinase: CLK1, 10ug (Human, recombinant; amino acids 129-end). MW: ~66kDa. Substrate: Native Swine Myelin Basic Protein (MBP). Other: Reaction Buffer, DTT. CLK1 NCBI Database Entry: www.ncbi.nlm.nih.gov/gene/1195/.