Anti-Coronavirus Antibodies and recombinant antigens
Antibodies from mouse with high affinity to the SARS-CoV-2 spike proteins
2019 Novel Coronavirus (SARS-CoV-2) is a coronavirus identified as the cause of an outbreak of respiratory illness. Its genome encodes four structural proteins, i.e. spike (S), envelope (E), membrane (M), and nucleocapsid (N).
The spike protein (S-protein) contains two subunits, S1 and S2. S1 defines the range of hosts and specificity of the virus, and thus recognizes and binds with the cell surface receptor. S2 subunit contains basic elements needed for membrane fusion.
The spike protein is the common target for immunodiagnostics reporting antibodies and for neutralizing antibodies and vaccines.
Three monoclonal antibodies from mouse with high affinity to the SARS-CoV-2 spike proteins are now available for use in various applications, including
- Western blot
- ELISA tests
- Rapid tests
- Flow cytometry
Five recombinant antigens for SARS-CoV-2 diagnostics and research applications
In addition to antibodies we offers a selection of recombinant protein antigens for coronavirus, expressed in E. coli and HEK293 cells, including the spike protein, host receptor ACE2, and the nucleocapsid protein. The spike protein of coronavirus is a large type I transmembrane protein divided into two functional units, S1 and S2. S1 facilitates virus infection by binding to host receptors, ACE2.
ACE2 is an exopeptidase that catalyses the conversion of angiotensin I to the nonapeptide angiotensin, or the conversion of angiotensin II to angiotensin 1-7. The nucleocapsid protein is the most abundant protein in coronavirus. It is a highly immunogenic phosphoprotein and is typically very conserved.
Please contact our Product Manager Pia Osenbroch - 950 08 180
For more information please download the Product Flyer.